Genesis Plus GX vs PicoDrive

Genesis Plus GX is a free, open-source emulator for Sega's 8-bit and 16-bit systems, including SG-1000, Mark-III, Master System, Game Gear, Genesis/Mega Drive, and Sega/Mega CD. It supports backward-compatibility modes and describes its CPU, video, and sound emulation as highly accurate, with cycle-accurate CPU and sound synchronization. The emulator reads raw and interleaved ROMs, as well as CUE+BIN, ISO+WAV, and ISO+OGG CD images. Emulated peripherals include 2-, 3-, and 6-button pads, multitaps, the Sega Mouse, and light guns; supported cartridge hardware includes SVP DSP, EEPROMs, Game Genie, Action Replay, and Lock-On. Standalone builds are available for GameCube and Wii, and the project lists access through frontends such as RetroArch, BizHawk, and OpenEmu. It describes compatibility with released software for its supported systems, while noting that it cannot test every game from start to finish. Some Master System games depend on particular hardware or VDP modes. The multi-platform core source is under a non-commercial license.

PicoDrive is a freeware, open-source emulator for Sega 8-bit and 16-bit consoles through the 32X. It runs Mega Drive/Genesis, Sega/Mega CD, 32X, Sega Pico, SG-1000, SC-3000, Master System/Mark III, and Game Gear games, with save states. The emulator supports enhanced CD audio for compatible cartridge games in MSU, MD+/32X+ and Mode 1 formats loaded from CUE or CHD files. Sega Pico Storyware pages and pad overlays can be displayed from PNG files beside a cartridge image. Physical mice can emulate a Sega Mouse or Pico Pen, and keyboard support covers Sega Pico and SC-3000 devices, including a virtual overlay. SC-3000 cassette emulation accepts WAV and bitstream files and advances tapes when accessed. The project documents generic Unix-like and libretro builds. Release packages or ZIP archives are installed manually. Windows, Linux, and self-hosted use are listed. The PicoDrive plan costs nothing.