HAWC vs Rayyan

HAWC is a free web application for storing, displaying, and synthesizing data used in human health and environmental risk assessments. Its modules support study-quality evaluation, data extraction from human epidemiology, animal bioassay, and in vitro studies, evidence synthesis, and dose-response analysis. Assessment teams can assign managers, members, and reviewers role-based permissions for viewing, editing, and administration. Published material is viewable without an account, while collaboration on an ongoing assessment with EPA scientists requires a Login.gov account and approved EPA HAWC group access. Interactive visualizations connect studies, experiments, endpoints, and dose information. Users can download available datasets as Microsoft Excel files and export figures to PDF or other formats. Benchmark dose modeling is performed endpoint by endpoint at the EPA HAWC chemical manager’s discretion. HAWC supports most modern browsers, with Google Chrome preferred, and reports functionality errors with Internet Explorer.

Rayyan is a platform for teams carrying out systematic evidence reviews, with workflows intended to be transparent, auditable, and reproducible. Its process spans reference import, collaboration, deduplication, title and abstract screening, full-text screening, data extraction, risk-of-bias assessment, and reporting. ResearchPilot AI Reviewer screens articles against criteria set by the user and gives decisions with reasoning notes. The Analyzer suggests inclusion or exclusion with justification, while the researcher retains final decision-making. ResearchPilot can also extract answers to custom questions from PDFs and metadata, highlight relevant passages, and let users inspect the answers. References are imported from exported files rather than a direct database connection. The API offers programmatic access to reviews, references, decisions, and metadata, plus workflow automation and external integrations. Rayyan is available on Android, iOS, web, and through an API. The Free plan allows three active reviews and two free reviewers; paid options start at $8.33 a month per seat, billed annually. Free mobile access is limited; Essential and higher provide unlimited mobile access.