| Price from | Free | — |
| Free plan | Yes | — |
| Free trial | Yes | — |
| Open source | — | — |
| Windows | Yes | — |
| macOS | — | Yes |
| iOS | — | Yes |
| API | Yes | — |
| Plans published | 7 | 2 |
| Spec score · Pixel Art Software | 8.8 (#4) | 7.3 (#51) |
| Animation | Its timeline supports linked cels, onion skinning, animation tags, tag sequences and variable frame timing. | Its layer and timeline panel includes layer grouping, frame tagging, linked cels, frame duration, and onion skin. |
| Drawing tools | The editor provides 21 drawing and selection tools, with the independent listing describing 20 drawing and selection tools. | It includes tools such as pencil, eraser, move, line, shape, selection, color bucket, eyedropper, and color picker. |
| File compatibility | PixelAOI opens and saves Aseprite .ase/.aseprite files, but its native master format is .pxl. | Pixquare supports importing and exporting Aseprite files and exports PNG, GIF, MOV, and sprite sheets. |